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  • Title: Anion sensor-based ratiometric peptide probe for protein kinase activity.
    Author: Kikuchi K, Hashimoto S, Mizukami S, Nagano T.
    Journal: Org Lett; 2009 Jul 02; 11(13):2732-5. PubMed ID: 19552460.
    Abstract:
    A new fluorescent sensor consisting of Cd(II)-cylcen appended aminocoumarin and a substrate peptide for protein kinase A (PKA) has been designed. Upon phosphorylation by PKA, the metal complex moiety binds to a phosphorylated residue, which in turn displaces the coumarin fluorophore, and this event results in ratiometric change of excitation spectrum in neutral aqueous solution.
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