These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine.
    Author: Winkler JD, Isaacs A, Holderbaum L, Tatard V, Dahmane N.
    Journal: Org Lett; 2009 Jul 02; 11(13):2824-7. PubMed ID: 19552464.
    Abstract:
    The synthesis and biological evaluation of structurally simplified, metabolically stable cyclopamine-like Sonic Hedgehog (SHH) signaling inhibitors, i.e., 5, is described in four chemical steps from commercially available steroidal precursors. Biological evaluation of this cyclopamine analogue in two different systems establishes the high potency of 5 as a SHH signaling inhibitor. This approach provides important new lead structures for the development of new cancer chemotherapeutic agents based on the inhibition on SHH signaling.
    [Abstract] [Full Text] [Related] [New Search]