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  • Title: Lack of association of angiotensin-converting enzyme insertion/deletion polymorphism and myocardial infarction at very young ages.
    Author: Rallidis LS, Gialeraki A, Varounis C, Dagres N, Kotakos C, Travlou A, Lekakis J, Kremastinos DT.
    Journal: Biomarkers; 2009 Sep; 14(6):401-5. PubMed ID: 19552566.
    Abstract:
    We examined whether angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism is associated with the development of myocardial infarction (MI) at < or = 35 years of age. The study sample consisted of 201 patients with premature MI and 140 age- and sex-matched healthy individuals. No difference was found in the distribution of ACE genotypes between the patients and controls. A higher prevalence of the DD genotype among hypertensives was found compared with the non-hypertensive patients (62.5% vs 35.6%, p = 0.01). ACE polymorphism is not associated with the development of premature MI and this might be due to the low prevalence of hypertension in young coronary patients.
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