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  • Title: Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study.
    Author: Lee S, Wu J, Ma YL, Tsang A, Guo WJ, Sung J.
    Journal: Aliment Pharmacol Ther; 2009 Sep 15; 30(6):643-51. PubMed ID: 19552631.
    Abstract:
    BACKGROUND: No previous study has examined the comorbidity of Irritable Bowel Syndrome (IBS) and Generalized Anxiety Disorder (GAD) in a general population using standardized diagnostic methods. AIM: To examine the prevalence, comorbidity and risk correlates of IBS and GAD in a general population. METHODS: A random community-based telephone survey was conducted. The questionnaire covered symptoms of IBS, GAD, core depressive symptoms, help-seeking behaviour and functional impairment on the Sheehan Disability Scale. RESULTS: A total of 2005 participants completed the interview. The current prevalence of IBS was 5.4% and the 12-month prevalence of GAD was 4%. GAD was five times more common among IBS respondents than non-IBS respondents (OR: 5.84, P < 0.001), whereas IBS was 4.7 times more common among GAD respondents than among non-GAD respondents (OR: 6.32, P < 0.001). Core depressive symptoms (OR: 6.25, P < 0.01) and education level (OR: 5.918, P = 0.021) were risk correlates of GAD among IBS respondents. Comorbid respondents were more impaired than respondents having either disorder alone, but were not more likely to seek professional help than IBS-only respondents. CONCLUSION: Irritable Bowel Syndrome and GAD comorbidity was common and added to impairment in the community. The strong association between psychiatric morbidity and IBS observed in referral centres was not a consequence of increased help-seeking behaviour.
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