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  • Title: CNS and lung metastasis of sebaceous epithelioma in a dog.
    Author: Bettini G, Morini M, Mandrioli L, Capitani O, Gandini G.
    Journal: Vet Dermatol; 2009 Aug; 20(4):289-94. PubMed ID: 19552699.
    Abstract:
    Sebaceous epithelioma is a common canine cutaneous neoplasm characterized by a preponderance of basaloid cells with few well-differentiated sebocytes. It is considered a low-grade malignancy, as it may occasionally recur at the excision site; the possibility of lymph node metastasis is anecdotally reported, and distant metastases have never been observed. This case report presents the clinical and pathological features of a sebaceous epithelioma of the upper lip with a highly aggressive behaviour. The patient was a 9-year-old female dachshund that developed local recurrence 11 months after the excision of the primary sebaceous epithelioma and multiple lung and central nervous system metastases 5 months later. The designation epitheliomatous sebaceous carcinoma has been suggested for aggressive sebaceous epitheliomas, although differential criteria are still to be determined.
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