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  • Title: Clinicopathologic significance of CD105-assessed microvessel density in glottic laryngeal squamous cell carcinoma.
    Author: Zvrko E, Mikic A, Vuckovic L.
    Journal: Auris Nasus Larynx; 2010 Feb; 37(1):77-83. PubMed ID: 19553039.
    Abstract:
    OBJECTIVE: Intratumoral microvessel density (MVD) determined with the use of antibodies to endoglin (CD105) is considered to be an important prognostic marker in a variety of malignancies. The purpose of this study has been to analyze the clinicopathologic significance of CD105-assessed MVD in SCCs primary localized in glottic region of larynx. METHODS: Surgical specimens from 40 patients with resected glottic squamous cell carcinomas were immunostained for CD105. CD105-assessed MVD was calculated at 400x magnification. Using the mean MVD as a cut-off, tumors were classified in the "high MVD" group and in the "low MVD" group. Clinicopathologic data were collected retrospectively. RESULTS: The mean MVD assessed by CD105 in considered glottic SCCs was 12.3 (standard deviation [SD]=3.65). MVD varied among tissue samples from 5 to 21 (median 12.5). High MVD was significantly correlated with a more aggressive tumor phenotype, including T3-T4 tumor (Fisher exact test, P=0.004) and advanced clinical stage (Fisher exact test P=0.026). Kruskal-Wallis test identified significant relation between pT stages and CD105-assessed MVD (P=0.011). CD105-assessed MVD was significantly related to malignancy recurrence presence/absence (Mann-Whitney U-test P=0.023). Logistic regression in multivariate modality showed that MVD (odds ratio [OR] 2.29, P=0.033, 95% confidence interval [CI] 1.06-7.53) and advanced T category (T3-T4) (OR 4.11, P=0.026, 95% CI 2.38-9.46) were significantly related to malignancy recurrence presence/absence. Cox regression analysis revealed that expression of CD105 (P=0.031) and N status (P=0.014) were the independent factors for disease-free survival. CONCLUSION: High expression of CD105 correlated significantly with advanced T status and locoregional recurrence. The present preliminary results suggest that CD105-assessed MVD in primary glottic squamous cell carcinomas may identify patients at risk of disease recurrence.
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