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  • Title: Bioavailability of ciprofloxacin tablets in humans and its correlation with the dissolution rates.
    Author: Khan MK, Khan MF, Khan H, Mustafa G.
    Journal: Pak J Pharm Sci; 2009 Jul; 22(3):329-34. PubMed ID: 19553184.
    Abstract:
    Bioavailabilities of seven tablets of ciprofloxacin were determined. The correlation between in-vivo bioavailability parameters and in-vitro dissolution rates were studied. Ciprofloxacin concentration from the blood was determined by microbiological assay technique. The release pattern of ciprofloxacin from tablets, which were determined by dissolution USP paddle method and spectrophotometric method was used to determine the concentration. All the parameters of ciprofloxacin bioavailability i.e., Tmax, Cmax, AUC and absorption rate constant (Ka) showed no significant correlation with dissolution rates at T30%, T50%, T90% and dissolution at 30 mins with aims as in-vivo bioequvalence waiver. The value of dissolution test used as quality tool for predicting in-vivo performance of drug product is significantly enhanced, if the in-vivo-in-vitro relationship (correlation or association) is established.
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