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  • Title: Myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with diffuse tubulointerstitial nephritis.
    Author: Son D, Kanda H, Yamaguchi A, Kawabata K, Kawakami T, Kubo K, Higashihara M, Shimizu J, Uozaki H, Kuramochi S, Misaki Y, Takeuchi F, Yamamoto K.
    Journal: J Nephrol; 2009; 22(3):417-20. PubMed ID: 19557721.
    Abstract:
    Renal involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is characterized by focal segmental crescentic and/or necrotizing glomerulonephritis. Here, we report the case of a 66-year-old woman showing myeloperoxidase (MPO)-ANCA positivity and mononeuritis multiplex whose kidney biopsy revealed severe and diffuse tubulointerstitial nephritis despite the fact that crescentic necrotizing glomerulonephritis was focal. The mechanism of tubulointerstitial injury in ANCA-associated vasculitis remains unclear. Further studies are necessary to confirm the relationship between diffuse tubulointerstitial nephritis and ANCA-associated vasculitis.
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