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  • Title: First structural insights into the TpsB/Omp85 superfamily.
    Author: Jacob-Dubuisson F, Villeret V, Clantin B, Delattre AS, Saint N.
    Journal: Biol Chem; 2009 Aug; 390(8):675-84. PubMed ID: 19558323.
    Abstract:
    Proteins of the TpsB/Omp85 superfamily are involved in protein transport across, or assembly into, the outer membrane of Gram-negative bacteria, and their distant eukaryotic relatives exert similar functions in chloroplasts and mitochondria. The X-ray structure of one TpsB transporter, FhaC, provides the bases to decipher the mechanisms of action of these proteins. With two POTRA domains in the periplasm, a transmembrane beta barrel and a large loop harboring a functionally important motif, FhaC epitomizes the conserved features of the super-family.
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