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  • Title: Brainstem involvement in Sjögren's syndrome-related sensory neuronopathy.
    Author: Damasceno A, França MC, Zanardi VA, Nucci A.
    Journal: J Neuroimaging; 2010 Oct; 20(4):397-9. PubMed ID: 19558581.
    Abstract:
    BACKGROUND AND PURPOSE: Sensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Magnetic resonance imaging (MRI) studies have shown abnormalities limited to T2-weighted high signal intensity in the posterior columns. METHODS AND RESULTS: A 65-year-old woman with Sjögren syndrome had slowly progressive unsteadiness of gait and limb paresthesias. A blink reflex examination suggested a paramedian brainstem lesion, confirmed by MRI. CONCLUSIONS: Sjögren's syndrome-related SN may be associated with a more diffuse immune-mediated aggression, involving also the brainstem, and leading to some of the blink reflex abnormalities observed in nonparaneoplastic SN.
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