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  • Title: Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample.
    Author: Ma J, Sun J, Zhang H, Zhang R, Kang WH, Gao CG, Liu HS, Ma XH, Min ZX, Zhao WX, Ning QL, Wang SH, Zhang YC, Guo TW, Lu SM.
    Journal: Neurosci Lett; 2009 Sep 22; 462(2):105-8. PubMed ID: 19560517.
    Abstract:
    Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P=0.01) and rs3918342 (P=0.02), and a highly significant under-transmission between haplotype CAT (P=0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.
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