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  • Title: Assessing the environment for regulatory change for eicosapentaenoic acid and docosahexaenoic acid nutrition labeling.
    Author: Brownawell AM, Harris WS, Hibbeln JR, Klurfeld DM, Newton I, Yates A.
    Journal: Nutr Rev; 2009 Jul; 67(7):391-7. PubMed ID: 19566599.
    Abstract:
    This review examines issues related to the development of a recommended daily allowance or adequate intake, two of the categories of dietary reference intakes, for the long-chain omega-3 polyunsaturated fatty acids (omega-3 PUFAs), eicosapentaenoic acid (EPA, 20:5 n-3), and docosahexaenoic acid (DHA, 22:6 n-3). Although some have suggested a dietary intake of two servings of fatty fish per week or supplement intake of 500 mg/day EPA plus DHA, based on evidence from epidemiologic and clinical studies of cardiovascular benefit from regular fish or fish-oil consumption, supplementation with EPA and/or DHA may also have antidepressant and mood-stabilizing effects. Omega-3 PUFA biology is complex and chronic disease outcomes are sometimes difficult to prove, yet the possibility of benefit for a substantial portion of the population from increased omega-3 PUFA intake is a public health issue that must be addressed responsibly and be based on significant scientific evidence.
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