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  • Title: Orexins/hypocretins and aminergic systems.
    Author: Eriksson KS, Sergeeva OA, Haas HL, Selbach O.
    Journal: Acta Physiol (Oxf); 2010 Mar; 198(3):263-75. PubMed ID: 19566795.
    Abstract:
    Orexin/hypocretin neurones in the posterior hypothalamus are mutually connected with noradrenergic, serotonergic, dopaminergic, histaminergic, and cholinergic neurone systems. They activate these targets by direct post-synaptic and indirect pre-synaptic mechanisms and in turn receive inhibitory feedback and excitatory feed forward control. With respect to behavioural state control, orexin/hypocretin neurones are conducting the orchestra of biogenic amines. This review highlights the role of these players in the control of energy administration, sleep-wake architecture, cortical activation, plasticity, and memory functions in health and disease.
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