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  • Title: [Serum levels of pro-inflammatory cytokines in diabetic patients with peripheral neuropathic pain and the correlation among them].
    Author: Yu LN, Yang XS, Hua Z, Xie W.
    Journal: Zhonghua Yi Xue Za Zhi; 2009 Feb 24; 89(7):469-71. PubMed ID: 19567096.
    Abstract:
    OBJECTIVE: To investigate the change of serum levels of the pro-inflammatory cytokines: macrophage migration inhibition factor (MIF), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6), in patients with diabetic peripheral neuropathic pain (DPNP) and their role in the pathogenesis of related diseases. METHODS: Peripheral blood samples were collected from 28 patients with diabetes mellitus (DM) without complications, and gender ratio- and age-matched 32 patients with diabetic peripheral neuropathy (DPN), 28 patients with DPNP, and 28 normal controls. Dual-antibody ELISA was used to detect the serum MIF, TNF-alpha, and IL-6 levels. RESULTS: The serum MIF, TNF-alpha, and IL-6 levels of the DM, DPN, and DPNP groups were all significantly higher than those of the control group (P < 0. 001, P < 0.05). The serum MIF and TNF-alpha levels of the DPN and DPNP groups were all significantly higher than those of the DM group (P < 0.05 or P < 0.001), while there were not significant differences in the serum MIF and TNF-alpha levels between the DPN and DPNP groups (both P > 0.05). There was not significant difference in the serum IL-6 level among the DM, DPN, and DPNP groups as well (all P > 0.05). The correlation analysis show that the levels of MIF, TNF-alpha and IL-6 each other were positively correlated (r = 0.337, P < 0.01; r = 0.216, P < 0.001; r = 0.281, P < 0.05). CONCLUSIONS: The serum pro-inflammatory cytokines MIF, TNF-alpha, and IL-6 levels play an important role in the pathogenesis of DM and DPN, but may not play an important role in the development of DPNP.
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