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  • Title: Interactions of aromatic mannosyl disulfide derivatives with concanavalin A: synthesis, thermodynamic and NMR spectroscopy studies.
    Author: Murthy BN, Sinha S, Surolia A, Jayaraman N, Szilágyi L, Szabó I, Kövér KE.
    Journal: Carbohydr Res; 2009 Sep 08; 344(13):1758-63. PubMed ID: 19570526.
    Abstract:
    alpha-D-Mannopyranosyl units were attached to an aromatic scaffold through disulfide linkages to obtain mono- to trivalent glycosylated ligands for lectin binding studies. Isothermal titration calorimetric (ITC) measurements indicated that binding affinities of these derivatives to Concanavalin A (Con A) were comparable to or slightly higher than that of methyl alpha-D-mannopyranoside (K(a) values in the range of 10(4)M(-1)). The stoichiometries of the lectin-ligand complexes were in agreement with the formal valencies (1-3) of the respective ligands indicating cross-linking in interactions with the di- and trivalent derivatives. Multivalency effects could not, however, be observed with the latter. These ligands were shown to bind to the carbohydrate binding site of Con A using saturation transfer difference (STD) NMR competition experiments.
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