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  • Title: Progress toward the total synthesis of psymberin/irciniastatin A.
    Author: Brown LE, Landaverry YR, Davies JR, Milinkevich KA, Ast S, Carlson JS, Oliver AG, Konopelski JP.
    Journal: J Org Chem; 2009 Aug 07; 74(15):5405-10. PubMed ID: 19572569.
    Abstract:
    In this paper, we describe our synthesis of four key building blocks for the total synthesis of psymberin (1) and its C4 epimer (2). Despite early difficulties in processing material to the advanced intermediate stage, we have been successful in developing high-yielding syntheses for the pyran core, natural side chain, 4-epi side chain, and aryl fragments of the molecule. Our findings from the optimization process are presented herein.
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