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  • Title: In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound.
    Author: Okunishi J, Nishihara Y, Maeda S, Ikeda M.
    Journal: J Antibiot (Tokyo); 2009 Sep; 62(9):489-93. PubMed ID: 19575042.
    Abstract:
    The antimicrobial activities of N(4)-octyl-6,6-dimethyl-N(2)-(4-methylbenzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine (HM-242), a novel synthetic compound, were compared with those of chlorhexidine gluconate (CHG). HM-242 was a more potent microbicide than CHG in vitro; however, its minimal inhibitory concentrations were similar. In particular, HM-242 killed various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, both efficiently and rapidly. HM-242 also showed potent virucidal activity against enveloped viruses such as influenza virus and herpes simplex virus. These characteristics suggest that HM-242 may well be useful as an antiseptic.
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