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  • Title: Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer.
    Author: Anderson M, Wilcox K, Guericke M, Chu H, Wilson MV, Wilson E, Lucas K, Holmes AE.
    Journal: Chirality; 2010 May 05; 22(4):398-402. PubMed ID: 19575463.
    Abstract:
    Using exciton-coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host-guest complex formed with (+)-(S)-methamphetamine produced a negative bisignate-shaped ECCD spectrum, whereas the complex formed with (-)-(R)-methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States.
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