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  • Title: The role of RAGE in amyloid-beta peptide-mediated pathology in Alzheimer's disease.
    Author: Schmidt AM, Sahagan B, Nelson RB, Selmer J, Rothlein R, Bell JM.
    Journal: Curr Opin Investig Drugs; 2009 Jul; 10(7):672-80. PubMed ID: 19579173.
    Abstract:
    This review discusses current knowledge of the complex interactions between amyloid-beta (A beta) peptide, the receptor for advanced glycation endproducts (RAGE), and inflammatory mediators, focusing on the roles of such interactions in the pathogenesis of Alzheimer's disease. As a ubiquitous cell-surface receptor, RAGE demonstrates enhanced expression in an A beta-rich environment; the effects of RAGE on microglia, the blood-brain barrier and neurons are mediated through various signaling pathways. Relevant preclinical models illustrate that the A beta-RAGE interaction amplifies neuronal stress and the accumulation of A beta, impairs memory and learning, and exaggerates neuroinflammation. These findings suggest that RAGE may mediate a common proinflammatory pathway in neurodegenerative disorders.
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