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  • Title: Highly regio- and enantioselective organocatalytic conjugate addition of alkyl methyl ketones to a beta-silylmethylene malonate.
    Author: Chowdhury R, Ghosh SK.
    Journal: Org Lett; 2009 Aug 06; 11(15):3270-3. PubMed ID: 19580247.
    Abstract:
    (S)-N-(2-pyrrolidinylmethyl)pyrrolidine/trifluoroacetic acid (3:1) combination catalyzed the direct addition of alkyl methyl ketones to beta-dimethyl(phenyl)silylmethylene malonate at the methyl terminal with high yield and excellent regio- and enantioselectivity. The silyl group played crucial roles in regioselection and substrate reactivity.
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