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  • Title: Synthesis of fully substituted pyrazoles via regio- and chemoselective metalations.
    Author: Despotopoulou C, Klier L, Knochel P.
    Journal: Org Lett; 2009 Aug 06; 11(15):3326-9. PubMed ID: 19580307.
    Abstract:
    The full functionalization of the pyrazole ring was achieved by successive regioselective metalations using TMPMgCl x LiCl and TMP(2)Mg x 2 LiCl. Trapping with various electrophiles led to trisubstituted pyrazoles. An application to the synthesis of the acaricide Tebufenpyrad is reported.
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