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  • Title: Characteristics of modulators and substrates binding to rat liver adenylate kinase.
    Author: Pradhan TK, Criss WE.
    Journal: Enzyme; 1977; 22(4):283-7. PubMed ID: 195804.
    Abstract:
    The binding of adenine nucleotides to liver adenylate kinase was dependent on Mg2+ ions. Citric acid enhanced the binding of all metal-chelated radioactive nucleotides and indicated two observable binding sites for Mg3H-ADP and Mg3-ATP and one-half binding site for Mg3H-AMP. Two binding sites of Mg3H-ADP and one binding site for Mg3H-ATP were also observed in the absence of citric acid. Stoichiometric binding of 14C-citric acid to liver adenylate kinase varied with additions of different nucleotides. AMP prevented whereas ADP and ATP enhanced the binding of 14C-citric acid.
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