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  • Title: The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.
    Author: Lunniss GE, Barnes AA, Barton N, Biagetti M, Bianchi F, Blowers SM, Caberlotto L, Emmons A, Holmes IP, Montanari D, Norris R, Walters DJ, Watson SP.
    Journal: Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4022-5. PubMed ID: 19581086.
    Abstract:
    A novel small molecule NPY Y2 antagonist (3) identified from high throughput screening is described. A subsequent SAR study and optimisation programme based around this molecule is also described, leading to the identification of potent and soluble pyridyl analogue 36.
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