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  • Title: Food-dependent Cushing's syndrome.
    Author: Messidoro C, Elte JW, Castro Cabezas M, van Agteren M, Lacroix A, de Herder WW.
    Journal: Neth J Med; 2009 May; 67(5):187-90. PubMed ID: 19581669.
    Abstract:
    It has recently been proposed that other hormones than ACTH can control cortisol production in Cushing's syndrome with bilateral adrenal hyperplasia. We present a case of food-dependent Cushing's syndrome. After a positive response of cortisol production during mixed meals, several tests identified glucose-dependent insulinotropic polypeptide (GIP) as the driving hormone responsible for the cortisol overproduction. Identification of aberrant hormone receptor expression is of importance because it may create a possibility for pharmacological treatment.
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