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  • Title: Biofunctionalized tilted Fiber Bragg Gratings for label-free immunosensing.
    Author: Maguis S, Laffont G, Ferdinand P, Carbonnier B, Kham K, Mekhalif T, Millot MC.
    Journal: Opt Express; 2008 Nov 10; 16(23):19049-62. PubMed ID: 19581997.
    Abstract:
    We present a study aimed at developing a label-free optical fiber biosensor for detection and quantification of biomolecules in real-time. The biosensor based on a Tilted Fiber Bragg Grating (TFBG) transduces a binding event between the probe and target molecules into a change in the refractive index of the medium surrounding the fiber. This work describes the experimental results obtained with three methods for immobilizing biomolecular probes on a TFBG silica cladding surface. Bovine serum albumin (BSA) and anti-BSA are used to assess the performances of the TFBG based biosensor in each configuration.
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