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  • Title: Three-dimensional holographic imaging of living tissue using a highly sensitive photorefractive polymer device.
    Author: Salvador M, Prauzner J, Köber S, Meerholz K, Turek JJ, Jeong K, Nolte DD.
    Journal: Opt Express; 2009 Jul 06; 17(14):11834-49. PubMed ID: 19582098.
    Abstract:
    Photorefractive materials are dynamic holographic storage media that are highly sensitive to coherent light fields and relatively insensitive to a uniform light background. This can be exploited to effectively separate ballistic light from multiply-scattered light when imaging through turbid media. We developed a highly sensitive photorefractive polymer composite and incorporated it into a holographic optical coherence imaging system. This approach combines the advantages of coherence-domain imaging with the benefits of holography to form a high-speed wide-field imaging technique. By using coherence-gated holography, image-bearing ballistic light can be captured in real-time without computed tomography. We analyzed the implications of Fourier-domain and image-domain holography on the field of view and image resolution for a transmission recording geometry, and demonstrate holographic depth-resolved imaging of tumor spheroids with 12 microm axial and 10 microm lateral resolution, achieving a data acquisition speed of 8 x 10(5) voxels/s.
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