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  • Title: Rolloamides A and B, cytotoxic cyclic heptapeptides isolated from the Caribbean marine sponge Eurypon laughlini.
    Author: Williams DE, Yu K, Behrisch HW, Van Soest R, Andersen RJ.
    Journal: J Nat Prod; 2009 Jul; 72(7):1253-7. PubMed ID: 19583251.
    Abstract:
    Two cyclic heptapeptides, rolloamides A (1) and B (2), have been isolated from the Dominican marine sponge Eurypon laughlini. The structures of 1 and 2 were elucidated by a combination of spectroscopic analyses and chemical degradation. Rolloamide A (1), which was found to exist as two distinct conformers in C(5)D(5)N, exhibits growth suppressive activity against a panel of histologically diverse cancer cell lines.
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