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  • Title: [Effect of ethyron on carbohydrate metabolism in the myocardium].
    Author: Kovalev GV, Spasov AA.
    Journal: Farmakol Toksikol; 1976; 39(5):574-7. PubMed ID: 195836.
    Abstract:
    Tests staged on rats showed the hypertensive drug ethyron (ethylisothiuronium) to intensify the activity of the oxidative system and pentose cycle in the myocardium, to increase the pyruvate content, raise the redox potential of the lactate-pyruvate potential, to reduce the amount of lactate, heighten the activity of the lactate, malate dehydrogenases, glucose-6-phosphate and cytochrome-c-oxydase. In an isolated spontaneously contracting atrium ethyron abolished the suppressing effect of carbohydrate metabolism inhibitors (sodium fluoride and copper sulphate) on the intensity and frequency of contractions.
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