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  • Title: Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation.
    Author: Singh I, Vyle JS, Heaney F.
    Journal: Chem Commun (Camb); 2009 Jun 14; (22):3276-8. PubMed ID: 19587938.
    Abstract:
    Solid-phase oligonucleotide conjugation by nitrile oxide-alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.
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