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  • Title: Modeling and analysis of ChIP-chip experiments.
    Author: Gottardo R.
    Journal: Methods Mol Biol; 2009; 567():133-43. PubMed ID: 19588090.
    Abstract:
    Chromatin immunoprecipitation on microarrays, also known as ChIP-chip, is a popular technique for genome-wide localization of DNA-binding proteins. However, the high density (several million genomic sequences for small eukaryote genomes) and the high noise-to-signal ratio of microarrays make the analysis of ChIP-chip data very challenging. In this chapter, we review some of the issues involved in the analysis of ChIP-chip data and present a few statistical methods that can be used to overcome these issues and improve the detection of DNA-protein binding sites.
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