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  • Title: Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions.
    Author: Lamas MC, Leonardi D, Lambri OA, Bassani G, Barrera MG, Bolmaro RE, Salomon CJ.
    Journal: Pharm Dev Technol; 2010; 15(2):162-8. PubMed ID: 19589124.
    Abstract:
    Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drug:carrier interactions were analyzed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.
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