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  • Title: Sclerosing nevus with pseudomelanomatous features (nevus with regression-like fibrosis): clinical and dermoscopic features of a recently characterized histopathologic entity.
    Author: Ferrara G, Giorgio CM, Zalaudek I, Broganelli P, Pellacani G, Tomasini C, Argenziano G.
    Journal: Dermatology; 2009; 219(3):202-8. PubMed ID: 19590167.
    Abstract:
    BACKGROUND: Sclerosing nevi with pseudomelanomatous features or, else, nevi with regression-like fibrosis (NRLF) are histopathologic simulators of regressing melanoma. OBJECTIVE: We aimed at evaluating the clinical features in a series of NRLF. METHODS: Dermoscopic images of NRLF were re-evaluated according to the amount of regression, the presence of white/blue areas and the 7-point checklist. RESULTS: Forty-six lesions from 44 patients (M:F = 3.4:1; mean age: 42 years) were evaluated. Thirty-seven lesions were excised from the back, mostly from the scapular area. All the lesions were dermoscopically atypical, with large amounts of regression (>10% in 43 cases) and with coexistence of white and blue areas (41 cases). According to the 7-point checklist, 25 lesions were labeled as benign, probably because regression obscured other dermoscopic features of atypia. CONCLUSION: NRLF are mostly found in the convex area of the back. A better recognition of their clinicopathologic features can allow a more conservative management.
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