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  • Title: Antimalarial activity of azafluorenone alkaloids from the Australian tree Mitrephora diversifolia.
    Author: Mueller D, Davis RA, Duffy S, Avery VM, Camp D, Quinn RJ.
    Journal: J Nat Prod; 2009 Aug; 72(8):1538-40. PubMed ID: 19591451.
    Abstract:
    Mass-directed isolation of the CH2Cl2/MeOH extract from the roots of the Australian tree Mitrephora diversifolia resulted in the purification of the new azafluorenone alkaloid 5,8-dihydroxy-6-methoxyonychine (1) together with the known natural product 5-hydroxy-6-methoxyonychine (2). The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. Both compounds were isolated during a drug discovery program aimed at the identification of new antimalarial leads from a prefractionated natural product library. When tested against two different strains of the parasite Plasmodium falciparum (3D7 and Dd2), 2 displayed IC(50) values of 9.9 and 11.4 microM, respectively, while 1 showed minimal activity.
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