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  • Title: [Expression of the voltage-dependent anion channel gene in human ejaculated spermatozoa].
    Author: Xu X, Wang Y, Yu Z, Chen J, Guo M, Gui YT, Cai ZM.
    Journal: Zhonghua Nan Ke Xue; 2009 Jun; 15(6):493-8. PubMed ID: 19593987.
    Abstract:
    OBJECTIVE: To identify the genes involved in sperm motility. METHODS: We hybridized asthenospermia and normal motile sperm cDNA samples with the human whole genome Affymetrix chip to screen differentially expressed genes. Then we detected the mRNA expressions of the voltage-dependent anion channel genes (VDACs) in human organs and spermatozoa by RT-PCR and compared their expressions in the poor and normal motility spermatozoa. RESULTS: Differentially expressed genes VDACs were identified by analysis of the hybridization signals, including the 3 subtypes VDAC1, VDAC2 and VDAC3. The expression of VDAC2 mRNA was significantly decreased in the poor motility sperm (0.568 +/- 0.036), as compared with the healthy men (0.803 +/- 0.043, P < 0.01). CONCLUSION: The decreased expression of VDAC2 in the ejaculated spermatozoa is possibly associated with the reduction of sperm motility.
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