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Title: MYC gene amplification in double minute chromosomes in an aggressive large B-cell lymphoma with leukemic presentation: a case report. Author: Alseraye F, Padmore R, Wozniak M, McGowan-Jordan J. Journal: Cancer Genet Cytogenet; 2009 Jul 15; 192(2):76-8. PubMed ID: 19596258. Abstract: Double-minute chromosomes (dmin) are small chromatin particles that lack a centromere. They represent extrachromosomal form of gene amplification. Dmin are very rarely encountered in lymphoid neoplasms. We describe a case of a leukemic presentation of large B-cell lymphoma with dmin. Fluorescence in situ hybridization analysis identified these dmin as comprising MYC genes.[Abstract] [Full Text] [Related] [New Search]