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  • Title: MYC gene amplification in double minute chromosomes in an aggressive large B-cell lymphoma with leukemic presentation: a case report.
    Author: Alseraye F, Padmore R, Wozniak M, McGowan-Jordan J.
    Journal: Cancer Genet Cytogenet; 2009 Jul 15; 192(2):76-8. PubMed ID: 19596258.
    Abstract:
    Double-minute chromosomes (dmin) are small chromatin particles that lack a centromere. They represent extrachromosomal form of gene amplification. Dmin are very rarely encountered in lymphoid neoplasms. We describe a case of a leukemic presentation of large B-cell lymphoma with dmin. Fluorescence in situ hybridization analysis identified these dmin as comprising MYC genes.
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