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Pubmed for Handhelds

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  • Title: Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper.
    Author: Jensen TH, Nielsen L, Aasted B, Blixenkrone-Møller M.
    Journal: Vaccine; 2009 Aug 20; 27(38):5178-83. PubMed ID: 19596418.
    Abstract:
    Young mink kits (n=8) were vaccinated with DNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodies were induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN-gamma producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.
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