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  • Title: Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression.
    Author: Pires I, Queiroga FL, Alves A, Silva F, Lopes C.
    Journal: Anticancer Res; 2009 Jul; 29(7):2713-7. PubMed ID: 19596951.
    Abstract:
    BACKGROUND: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. MATERIALS AND METHODS: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. RESULTS: All tumours expressed membranous E-cadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed. However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001). CONCLUSION: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression. The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression.
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