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  • Title: Preparation and evaluation of a noninfectious monkey pox virus vaccine.
    Author: Olsen RG, Blakeslee JR, Mathes L, Nakano JH.
    Journal: J Clin Microbiol; 1977 Jul; 6(1):50-4. PubMed ID: 195980.
    Abstract:
    Monkey pox virus was mechanically disrupted by low temperature and high pressure into soluble and insoluble fractions. Soluble fractions elicited virus-neutralizing antibodies (1:20 to 1:160) in rabbits, whereas the insoluble (in saline) fractions did not (less than 1:5). No infectious virus was detected after the disruption procedure. Rhesus monkeys immunized with the soluble fraction elicited virus-neutralizing (1:1,200), complement-fixing (1:16), and hemagglutinating-inhibiting (1:80 to 1:160) antibody titers and were completely protected against monkey pox virus-induced disease. This model of monkey pox virus subunit vaccine preparation may prove to be useful in developing an efficacious noninfectious vaccinia vaccine for use in high-risk individuals.
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