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  • Title: 6-substituted indolo[1,2-c]quinazolines as new antimicrobial agents.
    Author: Rohini R, Shanker K, Reddy PM, Sekhar VC, Ravinder V.
    Journal: Arch Pharm (Weinheim); 2009 Sep; 342(9):533-40. PubMed ID: 19598289.
    Abstract:
    A series of 2-o-arylidineaminophenylindoles and their cyclic derivatives (indolo[1,2-c]quinazolines) were synthesized. The reactions occurred under relatively mild conditions and afforded the desired product in good yields. Molecular structures of the synthesized compounds were confirmed by IR, (1)H-NMR,( 13)C-NMR, MS spectra, and elemental analyses. Furthermore, all the final products were screened for in-vitro antibacterial activity against three Gram-positive and three Gram-negative bacteria and also tested for their inhibitory action against three strains of fungi. Compound IIc showed potent activity against all the bacterial (except S. typhimurium) and fungal strains. Especially, compounds IIi and IIj which have isoquinolyl and pyridyl substituents displayed potent antibacterial as well as antifungal activities compared to those of the respective standard drugs Ampicillin and Ketoconazole.
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