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  • Title: [A case of mesalazine-induced lung injury improved by only discontinuation of mesalazine].
    Author: Shimizu T, Hayashi M, Shimizu N, Kinebuchi S, Toyama J.
    Journal: Nihon Kokyuki Gakkai Zasshi; 2009 Jun; 47(6):543-7. PubMed ID: 19601534.
    Abstract:
    We reported a case of drug-induced lung injury associated with mesalazine. A 50-year-old woman was diagnosed as having ulcerative colitis and treated with mesalazine. After administration for 1 month, the patient developed dry cough, fever and bilateral pulmonary infiltrates. A bronchoalveolar lavage showed 6.5 x 10(5) cells/ml, with 58% lymphocytes and 20% eosinophils. Improvement in clinical symptoms and radiological abnormalities occurred spontaneously after discontinuation of mesalazine. Even though the signs and symptoms of mesalazine-induced lung injury are similar to those of the pulmonary involvement of inflammatory bowel disease, it is important to distinguish them differences.
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