These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Convenient method for modifying poly(dimethylsiloxane) with poly(ethylene glycol) in microfluidics.
    Author: Zhou J, Yan H, Ren K, Dai W, Wu H.
    Journal: Anal Chem; 2009 Aug 15; 81(16):6627-32. PubMed ID: 19601621.
    Abstract:
    This report describes a convenient and reproducible method for the covalent modification of poly(dimethylsiloxane) (PDMS) with poly(ethylene glycol) (PEG) chains to suppress nonspecific protein adsorption. PEG additives terminated with a vinyl group are added into the PDMS prepolymer; when the PDMS is thermally cured, the vinyl group reacts with the silane groups on the PDMS, which covalently link the PEG group to the PDMS network. The PEG-modified PDMS surfaces are characterized with FT-IR, X-ray photoelectron spectroscopy (XPS), and contact angle measurement. We also examined the modified PDMS for on-chip capillary electrophoresis and its capability of resisting nonspecific protein adsorption using bovine serum albumin (BSA) as a model. Based on our study, a molecular mechanism is given to successfully explain the surface properties of the modified PDMS surfaces.
    [Abstract] [Full Text] [Related] [New Search]