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  • Title: No evidence of HTLV-I infection in French patients with multiple sclerosis using the polymerase chain reaction.
    Author: Wattel E, Mariotti M, Bignon JD, Agis F, Gordien E, Muller JY, Hors J, Lefrère JJ.
    Journal: J Clin Pathol; 1991 Oct; 44(10):871-2. PubMed ID: 1960225.
    Abstract:
    The polymerase chain reaction (PCR), using three primer pairs in the pol, tax, and env regions of the HTLV-I genome, was unable to detect HTLV-I in the blood samples of 54 caucasian subjects with multiple sclerosis who were seronegative for HTLV-I/II. Seventeen HTLV-I/II seropositive (by ELISA and Western blot) subjects used as positive controls were positive with the three primer pairs. The PCR was negative in 47 healthy HTLV-I/II seronegative (by ELISA) subjects at low risk of HTLV-I infection used as negative controls. These results suggest that there is no association between the occurrence of HTLV-I sequences and the development of multiple sclerosis.
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