These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Histological and immunohistological investigations of acute rejection of the allografted rat lung].
    Author: Yamamoto R, Inoue K, Kishi A, Kinoshita H.
    Journal: Nihon Kyobu Geka Gakkai Zasshi; 1991 Oct; 39(10):1846-51. PubMed ID: 1960425.
    Abstract:
    In allografted rat lungs during acute rejection we studied mode of mononuclear cell infiltration histologically, and changes in the relative proportion of T cell subsets immunohistochemically. Orthotopic lung transplantations were performed in PT1-incompatible rat strains (n = 37). The transplanted rat lungs were examined using H-E staining and immunohistochemical staining with antirat-lymphocyte monoclonal antibody. Histological investigation showed the site of mononuclear cell infiltration shifted rapidly from larger vessels to smaller vessels, and finally to alveolar region within three days. Immunohistochemically, helper T cells were more abundant than cytotoxic-suppressor T cells until day 3. However, the ratio of helper to cytotoxic-suppressor T cells were reversed on day 4 when cytotoxic-suppressor T cells were most abundant. This rapid change in the proportion of T cell subsets has not been reported for other organ transplants. Why lung allografts are rejected more rapidly than other organs may be explained by the sudden change in T cell subsets together with the rapid shift in the site of cellular infiltration.
    [Abstract] [Full Text] [Related] [New Search]