These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Locomotion disturbances in Huntington's disease].
    Author: Delval A, Krystkowiak P.
    Journal: Rev Neurol (Paris); 2010 Feb; 166(2):213-20. PubMed ID: 19604530.
    Abstract:
    In Huntington's disease (HD), perturbed locomotion occurs early in the course of the disease and presents numerous clinical features. The gait disorders in HD might best be defined as a timing disorder; however, hypokinesia (i.e. a decrease in stride length) also plays an important role in disturbed locomotion as HD progresses. Gait impairments are particularly important because they lead to an increased risk of falls. Falls risk factors and consequences depend on the stage of the disease. A satisfactory therapeutic strategy for gait impairments is a serious challenge: the use of a metronome during gait in HD patients does not effectively improve their gait. Attention deficits in HD may be a major determinant of this failure. The effect of antichoreic medications on gait is still controversial because of the absence of specific evaluation of these medications on gait disturbances.
    [Abstract] [Full Text] [Related] [New Search]