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  • Title: Drug-induced acute pancreatitis in children receiving chemotherapy for acute leukemia: does propofol increase the risk?
    Author: Crawford MW, Pehora C, Lopez AV.
    Journal: Anesth Analg; 2009 Aug; 109(2):379-81. PubMed ID: 19608806.
    Abstract:
    BACKGROUND: The use of propofol is controversial in patients with a history of acute pancreatitis or those taking drugs, including certain chemotherapeutic drugs, that are associated with pancreatitis. METHODS: To investigate this issue, we reviewed the medical records of all children who were diagnosed with pancreatitis while receiving chemotherapy for acute leukemia during a 5-year period. RESULTS: A temporal relationship between propofol use and development of acute pancreatitis could not be established. CONCLUSION: Propofol can be considered for general anesthesia in children who are receiving chemotherapeutic drugs that are themselves associated with acute pancreatitis or those who have a history of chemotherapy-induced pancreatitis.
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