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  • Title: Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp. GB 4-2.
    Author: Schulz D, Nachtigall J, Riedlinger J, Schneider K, Poralla K, Imhoff JF, Beil W, Nicholson G, Fiedler HP, Süssmuth RD.
    Journal: J Antibiot (Tokyo); 2009 Sep; 62(9):513-8. PubMed ID: 19609293.
    Abstract:
    Piceamycin, a new macrolactam polyketide antibiotic, was detected by HPLC-diode array screening in extracts of Streptomyces sp. GB 4-2, which was isolated from the mycorrhizosphere of Norway spruce. The structure of piceamycin was determined by mass spectrometry and NMR experiments. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and protein tyrosine phosphatase 1B.
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