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  • Title: Mediastinal yolk sac tumor. The Indiana University experience, 1976 to 1988.
    Author: Saxman S, Nichols CR, Williams SD, Loehrer PJ, Einhorn LH.
    Journal: J Thorac Cardiovasc Surg; 1991 Dec; 102(6):913-6. PubMed ID: 1960997.
    Abstract:
    Mediastinal yolk sac tumor (endodermal sinus tumor) is an extremely rare extragonadal germ cell neoplasm that has been associated with a grave prognosis. Twenty-one male patients with mediastinal yolk sac tumor received treatment at Indiana University between 1976 and 1988. Fourteen were seen after initial diagnosis, and their disease was treated with cisplatin-based chemotherapy in association with complete surgical resection if possible. Five are currently alive and disease free (36%). Seven were referred for salvage chemotherapy after relapse of their disease. Despite aggressive chemotherapy, these patients all died; they had a median survival time of 6 months. Our experience suggests that an aggressive combined modality approach with cisplatin-based chemotherapy followed by surgical resection of residual disease is the optimal management of this tumor. New regimens need to be explored for relapse of the disease after initial chemotherapy.
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