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  • Title: The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats.
    Author: Kawaura K, Ogata Y, Inoue M, Honda S, Soeda F, Shirasaki T, Takahama K.
    Journal: Behav Brain Res; 2009 Dec 14; 205(1):315-8. PubMed ID: 19616036.
    Abstract:
    The antidepressant-like effect of tipepidine was studied in rats. Tipepidine at 20 and 40 mg/kg i.p. reduced immobility in the forced swimming test and tipepidine at 40 mg/kg, i.p. increased climbing in the test. The drug at 40 mg/kg, i.p. had no effect on the locomotor activity and motor coordination. These results suggest that tipepidine may be a novel drug with antidepressant-like activity.
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