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  • Title: [ACTH activates in vitro protein kinases A and C in human adrenal cortex].
    Author: Kovzun OI, Tron'ko MD, Mykosha OS.
    Journal: Ukr Biokhim Zh (1999); 2005; 77(6):97-100. PubMed ID: 19618749.
    Abstract:
    The activation of protein kinases A and C by corticotropin in the human adrenal cortex was analyzed. ACTH influence in vitro significantly increase protein kinase A activity, total protein kinase C activity in the membrane fraction of adrenocorticocytes and 11-hydroxycorticosteroids production of adrenal cortex tissue. Either cAMP-dependent protein kinase A or protein kinase C are included to postreceptoral messenger mechanism, that mediates ACTH action in adrenocortical cells.
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