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  • Title: Oleanane-type triterpenoids from Aceriphyllum rossii and their cytotoxic activity.
    Author: Van le TK, Hung TM, Thuong PT, Ngoc TM, Kim JC, Jang HS, Cai XF, Oh SR, Min BS, Woo MH, Choi JS, Lee HK, Bea K.
    Journal: J Nat Prod; 2009 Aug; 72(8):1419-23. PubMed ID: 19618898.
    Abstract:
    The hexane-soluble fraction of the roots of Aceriphyllum rossii was used to isolate seven new oleanane-type triterpenoids, aceriphyllic acids C-I (1-7), together with seven known triterpenoids. The structures of aceriphyllic acids C-I were determined as 3alpha-hydroxyolean-12-en-23,29-dioic acid (1), 3beta-hydroxyolean-12-en-23,29-dioic acid (2), 3beta,23-dihydroxyolean-12-en-29-oic acid (3), 3alpha-O-acetylolean-12-en-23,27-dioic acid (4), 3alpha-O-caffeoylolean-12-en-27-oic acid (5), 3alpha-O-acetylolean-12-en-23,29-dioic acid (6), and 3alpha-hydroxyolean-12-en-23-al-27-oic acid (7) by spectroscopic analyses. In the evaluation of the in vitro cytotoxicity of these compounds against the MCF-7 and LLC cancer cell lines, compounds 10 and 13 exhibited cytotoxic activity against the LLC cancer cell line with IC(50) values of 7.63 and 6.56 microM, respectively.
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